Structure of PDB 8ugs Chain A

Receptor sequence
>8ugsA (length=816) Species: 9913 (Bos taurus) [Search protein sequence]
EEVEKFLDSNVSFAKQYYNLRYRAKVISDLLGPREAAVDFSNYHALNSVE
ESEIIFDLLRDFQDNLQAEKCVFNVMKKLCFLLQADRMSLFMYRARNGIA
ELATRLFNVHKDAVLEECLVAPDSEIVFPLDMGVVGHVALSKKIVNVPNT
EEDEHFCDFVDTLTEYQTKNILASPIMNGKDVVAIIMVVNKVDGPHFTEN
DEEILLKYLNFANLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTDIE
RQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAPPYAGPR
TPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLI
CNIMNAPSEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNR
KDGKPFDEMDETLMESLTQFLGWSVLNPDTYELMNKLENRKDIFQDMVKY
HVKCDNEEIQTILKTREVYGKEPWECEEEELAEILQGELPDADKYEINKF
HFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRRI
TYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGT
NNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHE
HAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLDQT
RKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQN
PIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNR
KEWKALADEYETKMKG
3D structure
PDB8ugs Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PCG A S95 F113 N114 F134 V140 F162 V166 D167 T170 Y172 T174 M193 V195 S89 F107 N108 F128 V134 F156 V160 D161 T164 Y166 T168 M187 V189
BS02 ZN A H563 H599 D600 D720 H557 H593 D594 D714
BS03 PCG A H559 D600 L671 D720 L721 Q773 F776 H553 D594 L665 D714 L715 Q767 F770
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0019933 cAMP-mediated signaling
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005886 plasma membrane
GO:0042622 photoreceptor outer segment membrane
GO:0042995 cell projection
GO:0097381 photoreceptor disc membrane

View graph for
Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:8ugs, PDBe:8ugs, PDBj:8ugs
PDBsum8ugs
PubMed38159849
UniProtP11541|PDE6A_BOVIN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Gene Name=PDE6A)

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