Structure of PDB 8uft Chain A

Receptor sequence
>8uftA (length=403) Species: 9606 (Homo sapiens) [Search protein sequence]
PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPAPEQLLSQA
RDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQA
WRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSA
ITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQH
GWTPGNGRFDVLPLLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALG
LRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDNHRYNILE
DVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASF
MKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQP
DPW
3D structure
PDB8uft Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase.
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A W178 R183 C184 F353 W356 E361 W447 F473 Y475 W101 R106 C107 F276 W279 E284 W370 F396 Y398
BS02 H4B A S102 R365 A446 W447 S37 R288 A369 W370
BS03 WK2 A V336 F353 W356 E361 W447 V259 F276 W279 E284 W370
BS04 ZN A C94 C99 C29 C34
BS05 H4B A F460 H461 Q462 E463 F383 H384 Q385 E386
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8uft, PDBe:8uft, PDBj:8uft
PDBsum8uft
PubMed38417024
UniProtP29474|NOS3_HUMAN Nitric oxide synthase 3 (Gene Name=NOS3)

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