Structure of PDB 8ufq Chain A

Receptor sequence
>8ufqA (length=417) Species: 9606 (Homo sapiens) [Search protein sequence]
PRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPRPEDVATKD
QLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELI
YGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNK
GNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFT
EICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFE
WFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTQIGVRDYCDNS
RYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHH
SATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTP
SFEYQPDPWNTHVWKLV
3D structure
PDB8ufq Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A W414 R419 C420 V421 M575 F589 S590 W592 Q597 W683 F709 Y711 W107 R112 C113 V114 M268 F282 S283 W285 Q290 W376 F402 Y404
BS02 ZN A C331 C336 C29 C34
BS03 H4B A F696 H697 Q698 E699 F389 H390 Q391 E392
BS04 H4B A S339 V682 W683 S37 V375 W376
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ufq, PDBe:8ufq, PDBj:8ufq
PDBsum8ufq
PubMed38417024
UniProtP29475|NOS1_HUMAN Nitric oxide synthase 1 (Gene Name=NOS1)

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