Structure of PDB 8udv Chain A

Receptor sequence
>8udvA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
ELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV
KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLMEY
AAKGNLREFLRARRSGEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARYKKTTNGRLPVKWMAPEALFDRVYTHQSD
VWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMI
MRECWHAAPSQRPTFKQLVEDLDRVLTVT
3D structure
PDB8udv Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
ChainA
Resolution2.348 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WIQ A E480 C482 F483 V486 A506 K508 E525 M529 M555 Y557 A558 G561 E565 L624 D635 L638 E23 C25 F26 V29 A49 K51 E68 M72 M98 Y100 A101 G104 E108 L155 D166 L169
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8udv, PDBe:8udv, PDBj:8udv
PDBsum8udv
PubMed38267212
UniProtP22607|FGFR3_HUMAN Fibroblast growth factor receptor 3 (Gene Name=FGFR3)

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