Structure of PDB 8udu Chain A

Receptor sequence
>8uduA (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
PADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKM
LKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA
KGNLREFLRARRSGEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAAR
NVLVTEDNVMKIADFGLANLDYYKGRLPVKWMAPEALFDRVYTHQSDVWS
FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRE
CWHAAPSQRPTFKQLVEDLDRVLTVTSHHH
3D structure
PDB8udu Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
ChainA
Resolution1.737 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WIQ A L478 C482 F483 V486 A506 E525 Y557 A558 N562 E565 L624 D635 L19 C23 F24 V27 A47 E66 Y98 A99 N103 E106 L153 D164
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8udu, PDBe:8udu, PDBj:8udu
PDBsum8udu
PubMed38267212
UniProtP22607|FGFR3_HUMAN Fibroblast growth factor receptor 3 (Gene Name=FGFR3)

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