Structure of PDB 8ucd Chain A

Receptor sequence
>8ucdA (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
ELFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVIN
KVLPMVSITLLALVYLPGVIAAIVQLHNKFPHWLDKWMLTRKQFGLLSFF
FAVLHAIYSLSYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYV
SLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHAL
IFAWNKWIDIKQFVWYTPPTFMIAVFLPIVVLIFKSILFL
3D structure
PDB8ucd AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity Against Prostate Cancer.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LBN A Q70 F170 V173 Q5 F100 V103
BS02 FAD A Y130 Q140 K162 G165 L233 H251 Q254 Y65 Q75 K92 G95 L163 H181 Q184
BS03 LBN A A228 A231 V235 V241 S244 A158 A161 V165 V171 S174
BS04 HEM A P119 H175 A176 G223 L227 H268 F272 P54 H105 A106 G153 L157 H198 F202
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0052851 ferric-chelate reductase (NADPH) activity
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0010008 endosome membrane
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8ucd, PDBe:8ucd, PDBj:8ucd
PDBsum8ucd
PubMed37861452
UniProtQ9UHE8|STEA1_HUMAN STEAP1 protein (Gene Name=STEAP1)

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