Structure of PDB 8ucc Chain A

Receptor sequence
>8uccA (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
VSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTT
VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLC
LVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH
RDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEI
TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYI
DKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA
3D structure
PDB8ucc The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)- N -(6-methylpyrazolo[1,5- a ]pyrimidin-3-yl)imidazo[1,2- a ]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.
ChainA
Resolution1.8 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WFQ A M192 V200 A211 Y262 Y264 M265 P266 G268 L318 M33 V41 A52 Y103 Y105 M106 P107 G109 L159
External links
PDB RCSB:8ucc, PDBe:8ucc, PDBj:8ucc
PDBsum8ucc
PubMed38467640
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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