Structure of PDB 8uc0 Chain A

Receptor sequence
>8uc0A (length=422) Species: 9606 (Homo sapiens) [Search protein sequence]
PLPLTALSPRRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHI
DWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWIKCGSVQ
QHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQ
LGTAVGFLLPPVLVPNTQNDTNLLACNISTMFYGTSAVATLLFILTAIAF
KEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTG
AFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTK
TYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLGFFMTGYLPLG
FEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIF
LCVWMFIGIILTALIKSDLRRH
3D structure
PDB8uc0 Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A L484 Y488 A492 F496 L388 Y392 A396 F400
BS02 Y01 A H145 W148 M204 C208 H49 W52 M108 C112
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015220 choline transmembrane transporter activity
GO:0015232 heme transmembrane transporter activity
GO:0020037 heme binding
GO:0022857 transmembrane transporter activity
GO:0034228 ethanolamine transmembrane transporter activity
Biological Process
GO:0001568 blood vessel development
GO:0001701 in utero embryonic development
GO:0006783 heme biosynthetic process
GO:0006839 mitochondrial transport
GO:0006879 intracellular iron ion homeostasis
GO:0008654 phospholipid biosynthetic process
GO:0015871 choline transport
GO:0015886 heme transport
GO:0030218 erythrocyte differentiation
GO:0034229 ethanolamine transport
GO:0035108 limb morphogenesis
GO:0035264 multicellular organism growth
GO:0042733 embryonic digit morphogenesis
GO:0043249 erythrocyte maturation
GO:0046620 regulation of organ growth
GO:0048536 spleen development
GO:0048704 embryonic skeletal system morphogenesis
GO:0055085 transmembrane transport
GO:0060323 head morphogenesis
GO:0097037 heme export
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uc0, PDBe:8uc0, PDBj:8uc0
PDBsum8uc0
PubMed38693265
UniProtQ9Y5Y0|FLVC1_HUMAN Heme transporter FLVCR1 (Gene Name=FLVCR1)

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