Structure of PDB 8uau Chain A

Receptor sequence

>8uauA (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]

FYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQ
TCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEPPCRKAK
EIRKERKRLKLMQQNPAGELEGFQALFPPKAKSNQPKSLEDLIFESLPEN
ASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEF
TRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSS
VYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPK
MKYKGQYRPSDLLCPETYVWVPIEQCLPSLEN

3D structure

PDB

8uau Oligomerization and a distinct tRNA-binding loop are important regulators of human arginyl-transferase function.

Chain

Resolution

5.7 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y21 Y25 Q299 E314 R317 F318 Y367 F408 I410	Y2 Y6 Q184 E199 R202 F203 Y252 F293 I295
BS02	rna	A	K88 S89 K91 K95 E112 C205 R206 K207 A208 I211 R212 R215 Q222 Q223 P251 Y298 Y369 Y370 D371 V381 Y418 K419	K69 S70 K72 K76 E93 C96 R97 K98 A99 I102 R103 R106 Q113 Q114 P136 Y183 Y254 Y255 D256 V266 Y303 K304

External links

PDB	RCSB:8uau, PDBe:8uau, PDBj:8uau
PDBsum	8uau
PubMed	39068213
UniProt	O95260\|ATE1_HUMAN Arginyl-tRNA--protein transferase 1 (Gene Name=ATE1)

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