Structure of PDB 8uak Chain A

Receptor sequence
>8uakA (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDV
ECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ
VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRNLKLDNVMLDSEGHIKIAD
FGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEM
LAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRL
GCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVPVLTPPDQLVIAN
IDQSDFEGFEYVNPQFVHP
3D structure
PDB8uak Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.
ChainA
Resolution2.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.13: protein kinase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W39 A L345 G346 F350 V353 T401 V420 D467 M470 D481 L14 G15 F19 V22 T70 V89 D136 M139 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8uak, PDBe:8uak, PDBj:8uak
PDBsum8uak
PubMed38198520
UniProtP17252|KPCA_HUMAN Protein kinase C alpha type (Gene Name=PRKCA)

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