Structure of PDB 8u8x Chain A

Receptor sequence
>8u8xA (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
MRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSP
KANKEDEAYVMAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDH
VRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHV
KITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYG
VTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW
MIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDDSTFYRSLLEDDDMGD
LVDAEEYL
3D structure
PDB8u8x Discovery of Potent and Selective Covalent Inhibitors of HER2 WT and HER2 YVMA.
ChainA
Resolution1.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W9N A G727 S728 A751 K753 S787 L789 T802 M805 C809 D812 R853 L856 T866 D867 F868 G16 S17 A40 K42 S74 L76 T89 M92 C96 D99 R140 L143 T153 D154 F155
External links
PDB RCSB:8u8x, PDBe:8u8x, PDBj:8u8x
PDBsum8u8x
PubMed38820338
UniProtP04626|ERBB2_HUMAN Receptor tyrosine-protein kinase erbB-2 (Gene Name=ERBB2)

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