Structure of PDB 8u6s Chain A

Receptor sequence
>8u6sA (length=544) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PISPIETVPVKLKPGMDGPKVKQWPTEEKIKALVEICTEMEKEGKISKIG
PENPYNTPVFAIKKKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKS
VTVLDVGDAYFSVPLDEDFRKYTAFTINNETPGIRYQYNVLPQGWKGSPA
IFQSSMTKILEPFAAQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQH
LLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQ
KLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAELELAENRE
ILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMR
GAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQA
TWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYV
TNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQA
QPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLV
3D structure
PDB8u6s Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase.
ChainA
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VPB A L100 K101 K102 V106 V108 Y181 Y188 F227 W229 H235 P236 Y318 L95 K96 K97 V101 V103 Y173 Y180 F219 W221 H227 P228 Y310
BS02 MG A D443 D498 H539 D435 D490 H531
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8u6s, PDBe:8u6s, PDBj:8u6s
PDBsum8u6s
PubMed37883896
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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