Structure of PDB 8u5x Chain A

Receptor sequence

>8u5xA (length=569) Species: 9606 (Homo sapiens) [Search protein sequence]

PSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPA
LLFKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTLLVASPDSRFSKA
GLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIG
FIFCEIQKWKDTQNASQNKIKIVGLGLLRVLQNPIVFMVFIGIAFNFILD
RKVPVYVENFLDGLGNSFSGSALFYLGLTMVGKIKRLKKSAFVVLILLIT
AKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFAT
QFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSF
DISIVSLISLIWSLAILLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWNF
VKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGII
IISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILI
AGISLMCMNQQLTRHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQ
FFCAVFNFGQGFISFGIFG

3D structure

PDB

8u5x Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.

Chain

Resolution

2.79 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	IAC	A	N145 F147 A148 A256 P327	N111 F113 A114 A222 P293

External links

PDB	RCSB:8u5x, PDBe:8u5x, PDBj:8u5x
PDBsum	8u5x
PubMed
UniProt	Q7Z3F1\|LYCHS_HUMAN Lysosomal cholesterol signaling protein (Gene Name=GPR155)

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