Structure of PDB 8u57 Chain A

Receptor sequence
>8u57A (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKSPFVIYDMNSLMMGED
KIEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVH
EIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVK
FNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKL
NHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVILHPLLQEIYKDLY
3D structure
PDB8u57 A structural basis for the activation of peroxisome proliferator-activated receptor gamma (PPAR gamma ) by perfluorooctanoic acid (PFOA).
ChainA
Resolution2.0 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8PF A V293 K301 V315 K319 L468 I472 V70 K78 V92 K96 L237 I241
BS02 8PF A E259 G284 C285 R288 S342 E49 G61 C62 R65 S119
BS03 8PF A C285 R288 S289 I326 Y327 L330 F363 H449 C62 R65 S66 I103 Y104 L107 F140 H226
BS04 8PF A V315 L318 E471 V92 L95 E240
External links
PDB RCSB:8u57, PDBe:8u57, PDBj:8u57
PDBsum8u57
PubMed38494006
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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