Structure of PDB 8u56 Chain A

Receptor sequence

>8u56A (length=541) Species: 9606 (Homo sapiens) [Search protein sequence]

MSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALL
FKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTLLVASPDSRFSKAGL
FPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFI
FCEIQKWKKIKIVGLGLLRVLQNPIVFMVFIGIAFNFILDRKVPVYVENF
LDGLGNSFSGSALFYLGLTMVGKIKRLKKSAFVVLILLITAKLLVLPLLC
REMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIIT
SGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSFDISIVSLISL
IWSLAILLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWNFVKEKNFVGQI
LVFVLLYSSLYSTYLWTGLLAISLFLLKKRVGIIIISGWGIPALLVGVLL
ISAFFYGKEQMITTAVTLFCSILIAGISLMCMNQLTRHVLLCLLLIIGLF
ANLSSCLWWLFNLYVELQFFCAVFNFGQGFISFGIFGLDKH

3D structure

PDB

8u56 Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.

Chain

Resolution

2.75 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	LMN	A	Y57 M264 I268 V348 F352	Y21 M220 I224 V304 F308
BS02	Y01	A	I280 I283 T284 I349 L660 L664	I236 I239 T240 I305 L490 L494

External links

PDB	RCSB:8u56, PDBe:8u56, PDBj:8u56
PDBsum	8u56
PubMed
UniProt	Q7Z3F1\|LYCHS_HUMAN Lysosomal cholesterol signaling protein (Gene Name=GPR155)

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