Structure of PDB 8u37 Chain A

Receptor sequence
>8u37A (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDV
ECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ
VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRNLKLDNVMLDSEGHIKIAD
FGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEM
LAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRL
GCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKGQPVLTPPDQLVIA
NIDQSDFEGFEYVNPQFVHP
3D structure
PDB8u37 Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.
ChainA
Resolution2.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.13: protein kinase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V5U A G346 V353 E418 Y419 V420 D467 M470 A480 D481 G15 V22 E87 Y88 V89 D136 M139 A149 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8u37, PDBe:8u37, PDBj:8u37
PDBsum8u37
PubMed38198520
UniProtP17252|KPCA_HUMAN Protein kinase C alpha type (Gene Name=PRKCA)

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