Structure of PDB 8u2s Chain A

Receptor sequence
>8u2sA (length=653) Species: 5671 (Leishmania infantum) [Search protein sequence]
SNVVEPTEANGKKSHVGPHLGSRMRIYEYSIEHNDAFWAEIARRDFYWKT
TWPDDQHVKSYNFDKSKGPIFVKWFEGAVTNVCYNALDRHLPAHKDRVCF
YFEGNDPSVTEAVTYGSMYTRVVELANVLKYQYGIAKGDRVGLYLPMIPF
AAVAMLACARIGAVITVIFGGFSAQALSSRLKDAQTKLLITADASARGTK
PIPLKDVADEALKECEEEGMSIACLVAENMMKRDTWYGDALARLTPEQHE
ECPVEWMDAEDVLFLLYTSGSTGKPKAIVHTTAGYMVYASTTFMYSFDYH
MDDVYFCTADIGWITGHSYVVYGPMIHCATSVLFEGVPNYPDYSRWWQLV
EKYKVSILYTAPTAIRSLMQAGDDYVKVGNRSTLRVLGSVGEPINVEAWK
WLRDVGGEGHCDVSDTWWQTETGGHMITPMPGCTPMKPGSATLPFFGVQP
VILDPMKLHEKQGPAEGLLAIRAPWPGMARTIYGDHARFEKTYFGVDGYY
MTGDGARRDSDGYYWITGRVDDVLNVSGHRIGTSEIEDAVNTHPAVVESA
VVGFPHNIKGEGIYVFLTFRQGTEVTPELLAAVKATVRKVIGPLATPDVM
QVARVGLPKTRSGKIVRRILRKVSAGQYTELDTSTLANPDVVEDLIAEHQ
RLC
3D structure
PDB8u2s Crystal Structure of Acetyl-coenzyme A synthetase from Leishmania infantum (Ethyl AMP bound, P21 form)
ChainA
Resolution2.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.1: acetate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WTA A I362 G439 E440 P441 T464 W465 W466 Q467 T468 D552 I564 R567 N573 R578 I314 G391 E392 P393 T416 W417 W418 Q419 T420 D504 I516 R519 N525 R530
Gene Ontology
Molecular Function
GO:0003987 acetate-CoA ligase activity
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0016874 ligase activity
Biological Process
GO:0006085 acetyl-CoA biosynthetic process
GO:0019427 acetyl-CoA biosynthetic process from acetate

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8u2s, PDBe:8u2s, PDBj:8u2s
PDBsum8u2s
PubMed
UniProtA4I093

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