Structure of PDB 8u2r Chain A

Receptor sequence
>8u2rA (length=664) Species: 5671 (Leishmania infantum) [Search protein sequence]
DSNVVEPTEANGKKSHVGPHLGSRMRIYEYSIEHNDAFWAEIARRDFYWK
TTWPDDQHVKSYNFDKSKGPIFVKWFEGAVTNVCYNALDRHLPAHKDRVC
FYFEGNDPSVTEAVTYGSMYTRVVELANVLKYQYGIAKGDRVGLYLPMIP
FAAVAMLACARIGAVITVIFGGFSAQALSSRLKDAQTKLLITADASARGT
KPIPLKDVADEALKECEEEGMSIACLVAENMNRQSCKMKEGRDTWYGDAL
ARLTPEQHEECPVEWMDAEDVLFLLYTSGSTGKPKAIVHTTAGYMVYAST
TFMYSFDYHMDDVYFCTADIGWITGHSYVVYGPMIHCATSVLFEGVPNYP
DYSRWWQLVEKYKVSILYTAPTAIRSLMQAGDDYVKVGNRSTLRVLGSVG
EPINVEAWKWLRDVGGEGHCDVSDTWWQTETGGHMITPMPGCTPMKPGSA
TLPFFGVQPVILDPMKLHEKQGPAEGLLAIRAPWPGMARTIYGDHARFEK
TYFGVDGYYMTGDGARRDSDGYYWITGRVDDVLNVSGHRIGTSEIEDAVN
THPAVVESAVVGFPHNIKGEGIYVFLTFRQGTEVTPELLAAVKATVRKVI
GPLATPDVMQVARVGLPKTRSGKIVRRILRKVSAGQYTELGDTSTLANPD
VVEDLIAEHQRLCS
3D structure
PDB8u2r Crystal Structure of Acetyl-coenzyme A synthetase from Leishmania infantum (Ethyl AMP bound)
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.1: acetate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WTA A I362 G439 E440 P441 T464 W465 W466 Q467 T468 D552 I564 R567 R578 I323 G400 E401 P402 T425 W426 W427 Q428 T429 D513 I525 R528 R539
Gene Ontology
Molecular Function
GO:0003987 acetate-CoA ligase activity
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0016874 ligase activity
Biological Process
GO:0006085 acetyl-CoA biosynthetic process
GO:0019427 acetyl-CoA biosynthetic process from acetate

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8u2r, PDBe:8u2r, PDBj:8u2r
PDBsum8u2r
PubMed
UniProtA4I093

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