Structure of PDB 8u2o Chain A

Receptor sequence
>8u2oA (length=289) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
GSMNIDISNFDFLYVIGKGTYGIVYKALDKKENNFVAIKKINLNDENYGI
SKRILRELTILQKIKHKNIINLKYVFYGKDIENSCLYLAFEYCDIDLFNL
IKKHNLNIKEIKYIIFELLLALSYFHSNNYIHRDIKPENIFITSEGEIKL
GDLGMSVEKSDHMTPTVVTLWYRAPEILLKSTNYDQKVDIWSLGCLFMEL
IQGRPLFPGKNDNTQLELIYLLLGDKDALTTVDKERKDMFPYFEINMLKD
AIDDEHTLDLISKMLIYDPNYRISSKEALKHPCFQDIEQ
3D structure
PDB8u2o Crystal Structure of Cdk-related protein kinase 6 (PK6) from Plasmodium falciparum in complex with inhibitor TCMDC-123995
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V3O A G16 K17 G18 V23 A36 I70 F99 Y101 C102 F150 D161 G17 K18 G19 V24 A37 I70 F90 Y92 C93 F141 D152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016592 mediator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8u2o, PDBe:8u2o, PDBj:8u2o
PDBsum8u2o
PubMed
UniProtQ8IDW1

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