Structure of PDB 8u27 Chain A

Receptor sequence
>8u27A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDDVEENRTEAPEGTESE
VVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDG
VNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQD
NGGWDAFVELYGPSMRPLFDFSWLSLK
3D structure
PDB8u27 Structural insights for selective disruption of Beclin 1 binding to Bcl-2
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ULL A F71 M74 L78 L80 A85 R88 V92 A108 F112 M116 W173 L174 L176 F71 M74 L78 L80 A85 R88 V92 A108 F112 M116 W173 L174 L176
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:8u27, PDBe:8u27, PDBj:8u27
PDBsum8u27
PubMed37875561
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2);
Q07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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