Structure of PDB 8u1w Chain A

Receptor sequence
>8u1wA (length=162) Species: 1241973 (Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU) [Search protein sequence]
APPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPQSAKEFFGVPIKQIQIH
KSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVATLLIKRPTGELMPLAAR
MGTHATMKIQGRTVGGQMGMLLLGTTPGDCGCPYIYKRGNDYVVIGVHTA
AARNTVICATQG
3D structure
PDB8u1w Crystal Structure of Inhibitor-Bound GII.4 Sydney 2012 Norovirus 3C-Like Protease.
ChainA
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FHR A H30 E54 Q110 R112 T134 P136 C139 H157 T158 A159 A160 H30 E54 Q110 R112 T125 P127 C130 H148 T149 A150 A151
BS02 FHR A A105 M107 V114 G116 M118 A160 A161 I168 A105 M107 V114 G116 M118 A151 A152 I157
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8u1w, PDBe:8u1w, PDBj:8u1w
PDBsum8u1w
PubMed38005879
UniProtK4L8Z7

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