Structure of PDB 8u1f Chain A

Receptor sequence
>8u1fA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP
LYVIVEYASKGNLREYLRARRPPEEQMTFKDLVSCTYQLARGMEYLASQK
CIHRDLAARNVLVTENNVMKIADFGRLPVKWMAPEALFDRVYTHQSDVWS
FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRD
CWHAVPSQRPTFKQLVEDLDRILTLT
3D structure
PDB8u1f Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
ChainA
Resolution3.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UIM A L487 E489 C491 F492 V495 E534 Y566 A567 R630 N631 L633 A643 F645 G646 L28 E30 C32 F33 V36 E75 Y107 A108 R159 N160 L162 A172 F174 G175
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8u1f, PDBe:8u1f, PDBj:8u1f
PDBsum8u1f
PubMed38300868
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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