Structure of PDB 8u17 Chain A

Receptor sequence
>8u17A (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
LHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFA
VLAYAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQQQAKV
QILPECVLPSTMSAVQLESLNKCQIFPSKPVSYKWWQKYQKRKFHCANLT
SWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACL
PIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIF
SLSLCGPMAAYVNPHGYVHETLTVYKACNIGRPSTEHSWFPGYAWTVAQC
KICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIP
3D structure
PDB8u17 Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C323 C326 C391 C235 C238 C300
BS02 Y70 A N351 P352 E377 H378 S379 W380 W386 N263 P264 E286 H287 S288 W289 W295
External links
PDB RCSB:8u17, PDBe:8u17, PDBj:8u17
PDBsum8u17
PubMed38086859
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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