Structure of PDB 8u15 Chain A

Receptor sequence
>8u15A (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]
LHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFA
VLAYREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDG
IQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPSYKWWQKYQKRKFH
CANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYR
VAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITT
KNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPG
YAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTKVIL
CL
3D structure
PDB8u15 Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C323 C391 C394 C240 C308 C311
BS02 8W7 A N351 P352 H378 W380 W386 W400 F402 N268 P269 H295 W297 W303 W317 F319
External links
PDB RCSB:8u15, PDBe:8u15, PDBj:8u15
PDBsum8u15
PubMed38086859
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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