Structure of PDB 8tzx Chain A

Receptor sequence
>8tzxA (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]
SCQVIPVLPQVMMILIPGQTLPLQLFRTFAVLAYSAQFGTTAEIYAYREE
QDFGIEIVKVKAIGRQRFKVLELRTQQAKVQILPECVLPSTMSAVQLESL
NKCQIFPSKPVSSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRI
KKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQR
LRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVH
ETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKK
DMSPQKFWGLTRSALLPTIPD
3D structure
PDB8tzx A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
ChainA
Resolution3.15 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N351 H353 Y355 W386 V388 Q390 H397 W400 N244 H246 Y248 W279 V281 Q283 H290 W293
BS02 ZN A C323 C326 C391 C394 C216 C219 C284 C287
BS03 U3I A N351 P352 H353 E377 H378 W380 W386 W400 F402 N244 P245 H246 E270 H271 W273 W279 W293 F295
External links
PDB RCSB:8tzx, PDBe:8tzx, PDBj:8tzx
PDBsum8tzx
PubMed38963839
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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