Structure of PDB 8tzg Chain A

Receptor sequence
>8tzgA (length=906) Species: 9606 (Homo sapiens) [Search protein sequence]
NRMKLMIVGNTGSGKTTLLQQTVGIDVKDWPLVLNVWDFAREEFYSTHPH
FMTQRALYLAVAMKPWLFNIKARASSSPVILVGTAIRDYHFVLAKLRKTI
INESLNFKIRDVELEKIILSERKNVPIEFPVIDRKRLLQLVRNELPHAVH
FLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILKGIISRRDVEKFM
SQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYE
MPYFPMGFWSRLINRLLEISPYMLSGALRPNRMYWRQGIYLNWSPEAYCL
VGSEVESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLTLLKKWAL
YSFNDGEEHQKILLDDLMKKAEEGDLLVNIPISQIAPDLILADLPRNIML
NNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTL
QHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGT
AQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTG
GRIVEGLKFPNEFDELEGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQER
PTSAQVFDILNSAELVCLTRILLPKNVIVECMVASIWLGCQLSFLILCLA
LVHIVSGTCLYCLLVGTGKLAIPLMCLSESVMWGGCGTKIFSFSIQKLIE
TRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLI
DCVHFLREVYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYN
FCNSVRVMMTAQNVMLVLGYNRIQSCLTVWDINLPHEVQNLEKHIEVRKE
LAEKMR
3D structure
PDB8tzg Inhibition of Parkinson Disease-related LRRK2 by Type I and Type II kinase inhibitors:activity and structures
ChainA
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1N A L1885 V1893 R1895 A1904 M1947 E1948 A1950 G1953 L2001 D2017 L415 V423 R425 A434 M477 E478 A480 G483 L531 D547
BS02 GDP A T1343 G1344 S1345 G1346 K1347 T1348 T1368 T1452 T11 G12 S13 G14 K15 T16 T22 T84
BS03 MG A T1348 T1368 T16 T22
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8tzg, PDBe:8tzg, PDBj:8tzg
PDBsum8tzg
PubMed38039358
UniProtQ5S007|LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (Gene Name=LRRK2)

[Back to BioLiP]