Structure of PDB 8tz1 Chain A

Receptor sequence
>8tz1A (length=533) Species: 9913 (Bos taurus) [Search protein sequence]
ERMCGRMSDFCREHKTTLRYIIWGILIAGYLALVIAACVMNFHRALPLFV
ITVVAIFFVVWDHLMAKYESQIARFLSPGQRLLDSHWFWLKWVIWGCLIL
GVILWLVFDTAKLGQQQLVSFGGLIIYTSLTFLFSKHPTKVYWRPVFWGI
GLQFLLGLLILRTEPGFMAFDWLGKQVQTFLGYSDAGASFVFGEKYTDHF
FAFKVLPIVIFFSTVMSMLYYLGLMQWIIRKVGWVMLVTMGTSPVESVVA
SGNIFIGQTESPLLVRPYLPYVTKSELHAIMTAGFSTIAGSVLGAYISFG
VSSSHLLTASVMSAPAALAISKLFWPETETPKINLKNAMKMESGDSRNLL
EAATQGASSSISLVANIAVNLIAFLALLSFMNSALSWLGNMFDYPQLSFE
VICSYVFMPFAFMMGVDWQDSFMVAKLIGYKTFFNEFVAYQQLSKLISLR
QVGGPKFVDGVQQYMSMRSEAISTYALCGFANFGSLGIVIGGLTSMAPSR
KRDITAGAMRALIAGTIACFLTACIAGMLTNTP
3D structure
PDB8tz1 Antiviral drug recognition and elevator-type transport motions of CNT3.
ChainA
Resolution2.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RBV A E349 V381 L452 E525 F526 E260 V292 L363 E436 F437
BS02 LBN A W184 W232 F236 F243 W95 W143 F147 F154
BS03 LBN A W176 G190 Y231 W237 G240 F243 W87 G101 Y142 W148 G151 F154
BS04 LBN A Q265 F269 Q176 F180
BS05 LBN A R599 I602 T605 R510 I513 T516
Gene Ontology
Molecular Function
GO:0005337 nucleoside transmembrane transporter activity
GO:0015213 uridine transmembrane transporter activity
GO:0015389 pyrimidine- and adenosine-specific:sodium symporter activity
GO:0015390 purine-specific nucleoside:sodium symporter activity
Biological Process
GO:0015855 pyrimidine nucleobase transport
GO:0015860 purine nucleoside transmembrane transport
GO:0015862 uridine transmembrane transport
GO:0015864 pyrimidine nucleoside transport
GO:0035725 sodium ion transmembrane transport
GO:0072531 pyrimidine-containing compound transmembrane transport
GO:1901642 nucleoside transmembrane transport
GO:1904823 purine nucleobase transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031526 brush border membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tz1, PDBe:8tz1, PDBj:8tz1
PDBsum8tz1
PubMed38418906
UniProtF1MGR1

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