Structure of PDB 8typ Chain A

Receptor sequence
>8typA (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
EDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGN
GSWVNEVLGPELPKCVPVCGVPREPFEEIIGGSDADIKNFPWQVFFDNPW
AGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSSKMLTPEHVFIHPG
WKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGD
LGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVAYVFTPNMICAGGEK
GMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVD
WIMKTMQENS
3D structure
PDB8typ Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide and Chemical Analogs
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.42: complement subcomponent C1s.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SQT A H475 D626 S627 K629 S654 W655 G656 P657 Y662 H116 D253 S254 K256 S281 W282 G283 P284 Y289
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8typ, PDBe:8typ, PDBj:8typ
PDBsum8typ
PubMed38149922
UniProtP09871|C1S_HUMAN Complement C1s subcomponent (Gene Name=C1S)

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