Structure of PDB 8txz Chain A

Receptor sequence
>8txzA (length=858) Species: 9606 (Homo sapiens) [Search protein sequence]
RMKLMIVGNTGKTTLLQQATVGIDVKDWLNVWDFAGREEFYSTHPHFMTQ
RALYLAVYDLKPWLFNIKARASSSPVILVGTPAIRDYHFVEKIILSERKN
VPIEFPVIDRKRLLQNELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPK
WLCKIMAQILTVPKGIISRRDVEKFYMSQYFKLLEKFQIALPIGEEYLLV
PSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYM
LSGALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRK
GCILLGQVVDHIDSLMEEWFPGLLTLLKKWALYSFNDGEEHQKILLDDLM
KKAEEGDLLVNIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDG
SFGSVYRAAYEGEEVAVKIFNHTSLRLLRQELVVLCHLHHPSLISLLAAG
IRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM
IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFR
APEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEQG
KLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCL
TRRILLPKNVIVECMVATASIWLGLSFLDLNTEGYCLACLYCLLVGCLSE
SNVMWGGCGTKIFSFIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLID
CVHFLREVMMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRLIRVIY
NFCNSVRVMMTAQLLKNVMLVLGYNQSCLTVWDINLPHEVQNLEKHIEVR
KELAEKMR
3D structure
PDB8txz Inhibition of Parkinson Disease-related LRRK2 by Type I and Type II kinase inhibitors: activity and structures
ChainA
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1N A L1885 V1893 A1950 G1953 R1957 L2001 A2016 L397 V405 A461 G464 R468 L512 A527
BS02 GDP A G1344 K1347 T1348 T1349 T1368 T1452 G11 K12 T13 T14 T20 T81
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8txz, PDBe:8txz, PDBj:8txz
PDBsum8txz
PubMed38039358
UniProtQ5S007|LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (Gene Name=LRRK2)

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