Structure of PDB 8txy Chain A

Receptor sequence
>8txyA (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
PHIGNYRLLKTLGKGNFAVVKLARHILTGKEVAIKIIDKTQLNSSSLQKI
FREVRIMKVLNHPNIIKLFEVIETEKTLYLVTEYAKNGEVFDYLVAHGRM
KEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFT
FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKEL
RERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGH
EDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATY
LLLGY
3D structure
PDB8txy Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SJ0 A M104 T129 E130 Y131 A132 K133 E136 E179 L182 M57 T82 E83 Y84 A85 K86 E89 E132 L135
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8txy, PDBe:8txy, PDBj:8txy
PDBsum8txy
PubMed38147543
UniProtQ7KZI7|MARK2_HUMAN Serine/threonine-protein kinase MARK2 (Gene Name=MARK2)

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