Structure of PDB 8tvt Chain A

Receptor sequence

>8tvtA (length=400) Species: 9606 (Homo sapiens) [Search protein sequence]

SLRPLYMDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAME
RARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQT
EHKCVLDSCRSLEAEGFQVTYLPVQKSGIIDLKELEAAIQPDTSLVSVMT
VNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSI
SGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPLVVGL
GAACEVAQQEMEYDHKRISKLSERLIQNIMKSLPDVVMNGDPKHHYPGCI
NLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHS
SIRFGIGRFTTEEEVDYTVEKCIQHVKRLREMSPLWEMVQDGIDLKSIKW

3D structure

PDB

8tvt D-Cysteine impairs tumor growth by inhibiting cysteine desulfurase NFS1

Chain

Resolution

2.0 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	A	G126 A127 T128 H156 D232 Q235 S255 H257 K258	G72 A73 T74 H102 D178 Q181 S201 H203 K204
BS02	LPH	A	Q64 A65 H156 N207 H257 K258 S379 C381 R407	Q10 A11 H102 N153 H203 K204 S325 C327 R353

External links

PDB	RCSB:8tvt, PDBe:8tvt, PDBj:8tvt
PDBsum	8tvt
PubMed
UniProt	Q9Y697\|NFS1_HUMAN Cysteine desulfurase (Gene Name=NFS1)

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