Structure of PDB 8tv7 Chain A

Receptor sequence
>8tv7A (length=170) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
SMEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGV
AGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPN
VNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRT
NVYLAVFDKNLYDKLVSSFL
3D structure
PDB8tv7 Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VI1 A D23 I24 G49 V50 A130 G131 A155 V156 F157 D23 I24 G49 V50 A130 G131 A155 V156 F157
External links
PDB RCSB:8tv7, PDBe:8tv7, PDBj:8tv7
PDBsum8tv7
PubMed38592023
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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