Structure of PDB 8tu4 Chain A

Receptor sequence
>8tu4A (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFI
EEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRF
QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLS
RYVLKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTN
SETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILD
VMDEES
3D structure
PDB8tu4 Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
ChainA
Resolution1.6 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V72 A L408 G409 A428 M477 A478 G480 C481 R525 L528 L15 G16 A35 M84 A85 G87 C88 R132 L135
External links
PDB RCSB:8tu4, PDBe:8tu4, PDBj:8tu4
PDBsum8tu4
PubMed38712838
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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