Structure of PDB 8tso Chain A

Receptor sequence
>8tsoA (length=573) Species: 562 (Escherichia coli) [Search protein sequence]
LSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGF
GKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFG
HMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGL
FIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTS
AEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQ
LIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNA
QFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDV
PALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHD
LREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARM
AYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDE
ATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVI
VERGTHNDLLEHRGVYAQLHKMQ
3D structure
PDB8tso Native mass spectrometry captures snapshots of the MsbA transport cycle
ChainA
Resolution2.68 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KDL A A181 R188 N235 R238 L239 K243 I250 L257 A175 R182 N229 R232 L233 K237 I244 L251
BS02 KDL A V29 Y83 Y87 C88 W91 V23 Y77 Y81 C82 W85
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0008559 ABC-type xenobiotic transporter activity
GO:0015437 lipopolysaccharide floppase activity
GO:0034040 ATPase-coupled lipid transmembrane transporter activity
GO:0042802 identical protein binding
Biological Process
GO:0006869 lipid transport
GO:0015920 lipopolysaccharide transport
GO:0034204 lipid translocation
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:1990199 MsbA transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tso, PDBe:8tso, PDBj:8tso
PDBsum8tso
PubMed
UniProtP60752|MSBA_ECOLI ATP-dependent lipid A-core flippase (Gene Name=msbA)

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