Structure of PDB 8trj Chain A

Receptor sequence
>8trjA (length=559) Species: 10114 (Rattus) [Search protein sequence]
CSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRK
EPLISSVHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFV
MTNYLKSEGQEQKLCPEYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIP
YDQKRKTCEIFAWCPAEEGKEAPRPALLRSAENFTVLIKNNIDFPGHNYT
TRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGENFTEVAVQGGIMGI
EIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYKENGM
EKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLI
INTYASTCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFV
DEPHIWMVDQQLLGKSLQDVKGQEVPRPQTDFLELSSPDWCQCGNCLPSQ
LPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLAL
EGEAINSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQG
QYSGFKYPY
3D structure
PDB8trj High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket
ChainA
Resolution2.78 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KD9 A R125 Q143 F288 R294 K311 R121 Q139 F284 R290 K307
BS02 GDP A R546 H547 Y550 A567 L569 R574 K583 S589 R510 H511 Y514 A531 L533 R538 K547 S553
BS03 ZN A C479 C499 C506 C572 C443 C463 C470 C536
BS04 ZN A C477 C479 C482 C441 C443 C446
BS05 KD9 A K64 K66 T189 V190 L191 I214 K60 K62 T185 V186 L187 I210
External links
PDB RCSB:8trj, PDBe:8trj, PDBj:8trj
PDBsum8trj
PubMed39107314
UniProtQ64663|P2RX7_RAT P2X purinoceptor 7 (Gene Name=P2rx7)

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