Structure of PDB 8tr5 Chain A

Receptor sequence
>8tr5A (length=553) Species: 10114 (Rattus) [Search protein sequence]
SWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKE
PLISSVHTKVKGVAEVTEKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEG
QEQKLCPEYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCE
IFAWCPAEEGKEAPRPALLRSAENFTVLIKNNIDFPGHNYTTRNILPGMN
ISCTFHKTWNPQCPIFRLGDIFQEIGENFTEVAVQGGIMGIEIYWDCNLD
SWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYKENGMEKRTLIKAF
GVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYASTCC
RSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVD
QQLLGKSLQDVKGQEVPRPQTDFLELSRLDSPDWCQCGNCLPSQLPENRR
ALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEAIN
SKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFK
YPY
3D structure
PDB8tr5 High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket
ChainA
Resolution2.53 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A R546 H547 Y550 A567 L569 R574 K583 Y588 S589 G590 R504 H505 Y508 A525 L527 R532 K541 Y546 S547 G548
BS02 ZN A C479 C499 C506 C572 C437 C457 C464 C530
BS03 ZN A C477 C479 C482 C435 C437 C440
External links
PDB RCSB:8tr5, PDBe:8tr5, PDBj:8tr5
PDBsum8tr5
PubMed39107314
UniProtQ64663|P2RX7_RAT P2X purinoceptor 7 (Gene Name=P2rx7)

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