Structure of PDB 8tr2 Chain A

Receptor sequence
>8tr2A (length=745) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEI
NKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDPLLIAGVI
GGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFY
QAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEK
VGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFT
WVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNH
RNPWFRDFWEQKFQCSLNHRCDKHLAIDSSNYEQESKIMFVVNAVYAMAH
ALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADS
IVKFDTFGDGMGRYNVFNLQQTGKYSYLKVGHWAETLSLDVDSIHWSRNS
VPTSQCSDPNEMKNMDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADL
SGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTASGRE
LCYILLFGVSLSYCMTFIAKPSPVICALRRLGLGTSFAICYSALLTKTNC
IARIFKNGSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVI
LKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQK
3D structure
PDB8tr2 Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization.
ChainA
Resolution3.5 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JIX A R64 R68 S149 Y150 A172 T174 Y222 D301 R35 R39 S103 Y104 A126 T128 Y176 D255
BS02 CA A P46 T98 Y150 V153 P17 T69 Y104 V107
BS03 CA A S152 Y222 R277 S106 Y176 R231
External links
PDB RCSB:8tr2, PDBe:8tr2, PDBj:8tr2
PDBsum8tr2
PubMed37645747
UniProtP31422|GRM3_RAT Metabotropic glutamate receptor 3 (Gene Name=Grm3)

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