Structure of PDB 8tqm Chain A

Receptor sequence
>8tqmA (length=843) Species: 1247190 (Saccharomyces cerevisiae BY4741) [Search protein sequence]
FSLLLSKSILTFFEKARLALTIGLAAVLYIIGVPLVWNMFGKLYTMMLDG
SSPYPGDFLKSLIYGYDQSATPELTTRAIFYQLLQNHSFTSLQFIMIVIL
HIALYFQYDMIVREDVFSKMVFHKIGPRINLKLKLLNVIAYFIIAVVFTA
IYLAISYLFPTFIGFGLLKIYFGIFKVILRGLCHLYYLSWISDHLIHDII
YLYNGYTENTMKHSIFIRALPALTTYLTSVSIVCASSNLVSRGYGRENGM
SNPTRRLIFQILFALKCTFKVFTLFFIELAGFPILAGVMLDFSLFCPILA
SNSRMLWVPSICAIWPPFSLFVYWTIGTLYMYWFAKYIGMIRKNIIRPGV
LFFIRSPEDPNIKILHDSLIHPMSIQLSRLCLSMFIYAIFIVLGFGFHTR
IFFPFMLKSNLLSVPEAYKPTSIISWKFNTILLTLYFTKRILESSSYVKP
LLERYWKTIFKLCSRKLRLSSFILGKDTPTERGHIVYRNLFYKYIAAKNA
EWSNQELFTKPKTLEQAEELFGQVRDVHAYFVPDGVLMRVPSSDIVSRNY
VQTMFVPVTKDDKLLKPLDLERIKERNKRAAGEFGYLDEQNTEYDQYYIV
YVPPDFRLRYMTLLGLVWLFASILMLGVTFISQALINFVCSFGFLPVVKL
LLGERNKVYVAWKELSDISYSYLNIYYVCVGSVCLSKIAKDILHFTEGIF
MAIFNSIFDSMLVKYNLMVFIAIMIAVIRTMVSWVVLTDGILACYNYLDE
SLLFVVWIISSMVNFGTGYKSLKLFFRNRNTSKLNFLKTMALELFKQGFL
HMVIYVLPIIILSTRMQDIYFGLLIALESFTFFFQATVLFIQW
3D structure
PDB8tqm Substrate-recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A A635 W679 A280 W324
BS02 ERG A H213 I497 S584 H101 I163 S229
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0016567 protein ubiquitination
GO:0030970 retrograde protein transport, ER to cytosol
GO:0036503 ERAD pathway
Cellular Component
GO:0000837 Doa10p ubiquitin ligase complex
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tqm, PDBe:8tqm, PDBj:8tqm
PDBsum8tqm
PubMed38467638
UniProtP40318|DOA10_YEAST ERAD-associated E3 ubiquitin-protein ligase DOA10 (Gene Name=SSM4)

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