Structure of PDB 8tqb Chain A

Receptor sequence
>8tqbA (length=744) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEI
NKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKLLIAGVIGGS
YSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAK
AMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGR
SNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVA
SDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNP
WFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYA
MAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKG
ADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHW
SRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDC
GPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFI
SGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSAL
LTKTKFISPSSQVFICLGLILVQIVMVILETPGTRRYTLPEKRETVILKC
NVKDSSMLISLTYDVVLVILCTVYAFKTEAKFIGFTMYTTCIIWLAFLPI
FYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQK
3D structure
PDB8tqb Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization.
ChainA
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W92 A R64 R68 S149 Y150 S151 A172 S173 T174 Y222 D301 K389 R35 R39 S100 Y101 S102 A123 S124 T125 Y173 D252 K340
BS02 CA A S152 Y222 R277 S103 Y173 R228
BS03 CA A P46 T98 V153 P17 T69 V104
External links
PDB RCSB:8tqb, PDBe:8tqb, PDBj:8tqb
PDBsum8tqb
PubMed37645747
UniProtP31422|GRM3_RAT Metabotropic glutamate receptor 3 (Gene Name=Grm3)

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