Structure of PDB 8tpm Chain A

Receptor sequence
>8tpmA (length=615) Species: 660122 (Fusarium vanettenii 77-13-4) [Search protein sequence]
ESNFGVDFVIHYKVPAAERDEAEAGFVQLIRALTTVGLATEVRHGENESL
LVFVKVASPDLFAKQVYRARLGDWLHGVRVSAPHNDPVVEAERLRLIYLM
ITKPHNEGGAGVTPTNAKWKHVESIFPLHSHSFNKEWIKKWSSKYTLEQT
DIDNIRDKFGESVAFYFAFLRSYFRFLVIPSAFGFGAWLLLGQFSYLYAL
LCGLWSVVFFEYWKKQEVDLAVQWGVRGVSSIQQSRPEFEWEHEAEDPIT
GEPVKVYPPMKRVKTQLLQIPFALACVVALGALIVTCNSLEVFINEVYPG
KQYLGFLPTIFLVIGTPTISGVLMGAAEKLNAMENYATVDAHDAALIQKQ
FVLNFMTSYMALFFTAFVYIPFGHILHPFLNFWRATAQTFQINPARISNQ
MFYFTVTAQIVNFATEVVVPYEDHEEEAEFLQRVREECTLEEYDVSGDYR
EMVMQFGYVAMFSVAWPLAACCFLVNNWVELRSDALKIAISSRRPIPWRT
DSIGPWLTALSFLSWLGSITSSAIVYLCSNLKAWGLLLSILFAEHFYLVV
QLAVRFVLSKLDSPGLQKERKERFQTKKRLLQENLTPEEMFWQRQRGMQE
TIEIGRRMIEQQLAA
3D structure
PDB8tpm Structural basis of closed groove scrambling by a TMEM16 protein.
ChainA
Resolution2.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGW A F622 K626 F556 K560
BS02 PGW A W600 L607 H611 W534 L541 H545
BS03 PGW A F391 A599 F367 A533
BS04 PGW A T563 F567 W570 T508 F512 W515
BS05 PGW A Q372 F375 F379 P560 T563 Q348 F351 F355 P505 T508
BS06 PGW A Q288 I292 Q266 I270
BS07 PGW A V230 L624 V208 L558
BS08 PGW A N435 F438 W521 N399 F402 W466
Gene Ontology
Molecular Function
GO:0005254 chloride channel activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0032541 cortical endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tpm, PDBe:8tpm, PDBj:8tpm
PDBsum8tpm
PubMed38684930
UniProtC7Z7K1

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