Structure of PDB 8to4 Chain A

Receptor sequence
>8to4A (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREP
KANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVR
EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKI
TDFGLAKLLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD
GIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELII
EFSKMARDPQRYLVIQGDERMSPTDSNFYRALMDEEDMDDDADEYLIPQQ
3D structure
PDB8to4 EGFR(T790M/V948R) in complex with the allosteric inhibitor FRF-06-057
ChainA
Resolution2.99 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N842 D855 N139 D152
BS02 ANP A L718 G719 S720 G721 A722 F723 G724 V726 A743 K745 L792 M793 N842 L844 L18 G19 S20 G21 A22 F23 G24 V26 A43 K45 L89 M90 N139 L141
External links
PDB RCSB:8to4, PDBe:8to4, PDBj:8to4
PDBsum8to4
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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