Structure of PDB 8tmr Chain A

Receptor sequence
>8tmrA (length=263) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
NLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLA
AAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAV
QYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDA
RDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPA
DWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKKDDKHSEA
VIAAAARLALEGL
3D structure
PDB8tmr Klebsiella pneumoniae carbapenemase variant 44 (KPC-44) acquires ceftazidime-avibactam resistance by altering the conformation of active site loops.
ChainA
Resolution1.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NXL A S70 W105 S130 N132 N170 T216 T235 T237 S43 W78 S103 N105 N143 T189 T208 T210
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:8tmr, PDBe:8tmr, PDBj:8tmr
PDBsum8tmr
PubMed38000656
UniProtA0A4Y5JTU1

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