Structure of PDB 8tl8 Chain A

Receptor sequence
>8tl8A (length=334) Species: 10882 (Orthoreovirus) [Search protein sequence]
QQVCPNYVMLRSSVTTKVVRNVVEYQIRTGGFFSCLAMLRPLQYAKRERL
LGQRNLERISTRDILQTRDLHSLCMPTPDAPMSNHQASTMRELICSYFKV
DHADGLKYIPMDERYSPSSLARLFTMGMAGLHITTEPSYKRVPIMHLAAD
LDCMTLALPYMITLDGDTVVPVAPTLSAEQLLDDGLKGLACMDISYGCES
SRCINELYCEETAEAICVLKTCLVLNCMQFKLEMDDLAHNAAELDKIQMM
IPFSERVFRMASSFATIDAQCFRFCVMMKDKNLKIDMRETTRLWTRSASD
DSVATSSLSISLDRGRWVAADASDARLLVFPIRV
3D structure
PDB8tl8 Structure of Orthoreovirus RNA Chaperone SigmaNS R6A mutant in complex with bile acid
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GCH A L111 S114 L204 Y240 E242 A245 E246 L93 S96 L186 Y208 E210 A213 E214
BS02 GCH A T181 L182 A208 Y240 T163 L164 A190 Y208
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tl8, PDBe:8tl8, PDBj:8tl8
PDBsum8tl8
PubMed38503747
UniProtP03526|SIGNS_REOVD Protein sigma-NS (Gene Name=S3)

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