Structure of PDB 8tg9 Chain A

Receptor sequence

>8tg9A (length=426) Species: 9606 (Homo sapiens) [Search protein sequence]

GNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVL
GSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHW
RVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQA
LMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLL
RTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQG
GQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHL
AYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQ
RMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQE
LVAVSGRKLNWPLGYPPPDIPKCGFD

3D structure

PDB

8tg9 Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381

Chain

Resolution

3.08 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y88 Y154 F165 V168 E169 F172 M173 H185	Y88 Y154 F165 V168 E169 F172 M173 H185

External links

PDB	RCSB:8tg9, PDBe:8tg9, PDBj:8tg9
PDBsum	8tg9
PubMed
UniProt	P16066\|ANPRA_HUMAN Atrial natriuretic peptide receptor 1 (Gene Name=NPR1)

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