Structure of PDB 8tg4 Chain A

Receptor sequence
>8tg4A (length=182) Species: 56636 (Aeropyrum pernix) [Search protein sequence]
HMRVRLSKTLAGILRHHPGRYGVRLTREGWARVSEVVEGLRKAGWSWVEE
WHIVGVALHDPKGRYELRNGEIRARYGHSIPVNVEPLPGEPPPILYHGTT
EEALPLIMERGIMRGRRLKVHLTSSLEDAVSTGRRHGNLVAVLLVDVECL
RRRGLKVERMSKTVYTVDWVPPECIAEVRRES
3D structure
PDB8tg4 Structural basis for Tpt1-catalyzed 2'-PO 4 transfer from RNA and NADP(H) to NAD.
ChainA
Resolution1.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.-
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 rna A V3 S6 K7 G11 R14 H15 H16 R63 R115 R116 V4 S7 K8 G12 R15 H16 H17 R64 R116 R117
BS02 9SO A R14 K61 R63 Y75 H96 T98 L105 I106 I111 M112 R116 T131 R134 H135 R15 K62 R64 Y76 H97 T99 L106 I107 I112 M113 R117 T132 R135 H136
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8tg4, PDBe:8tg4, PDBj:8tg4
PDBsum8tg4
PubMed37883434
UniProtQ9YFP5|KPTA_AERPE Probable RNA 2'-phosphotransferase (Gene Name=kptA)

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