Structure of PDB 8tfp Chain A

Receptor sequence

>8tfpA (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]

ELTQPPSVSVSPGQTARITCSGDTLPKRSGYWYQQKPDQAPLLVINKDTE
RPSGIPERFSGSKSGTTVTLTISGVQAEDEADYYCQSADSSFTYPSFGGG
TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKA
DSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGS
TVEKTVAPT

3D structure

PDB

8tfp An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression.

Chain

Resolution

1.78 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	84K	A	Q89 F95 T95A P96	Q86 F92 T93 P95

External links

PDB	RCSB:8tfp, PDBe:8tfp, PDBj:8tfp
PDBsum	8tfp
PubMed	37534714

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