Structure of PDB 8te4 Chain A

Receptor sequence
>8te4A (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
GSAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMV
RHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYE
GTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLES
NPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIA
KFSKVRTHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSAMSHLARQRLL
GRSWSVPVIRHLFAPLKEYFACV
3D structure
PDB8te4 Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A F640 D641 G642 I643 T645 E664 V665 D686 V687 G707 R891 S892 W893 F15 D16 G17 I18 T20 E39 V40 D61 V62 G82 R252 S253 W254
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8te4, PDBe:8te4, PDBj:8te4
PDBsum8te4
PubMed38600075
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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