Structure of PDB 8tdr Chain A

Receptor sequence
>8tdrA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
GSAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMV
RHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYE
GTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLES
NPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIA
KFSKVRTHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLL
GRSWSVPVIRHLFAPLKEYFACV
3D structure
PDB8tdr Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain
ChainA
Resolution3.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A F640 D641 G642 T645 E664 V665 D686 V687 G707 R891 S892 W893 F15 D16 G17 T20 E39 V40 D61 V62 G82 R252 S253 W254
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8tdr, PDBe:8tdr, PDBj:8tdr
PDBsum8tdr
PubMed38600075
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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