Structure of PDB 8tdb Chain A

Receptor sequence
>8tdbA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGV
KLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVT
ISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLME
QLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRR
LAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGF
RSLLINAVEASCIRTRELQSMADQE
3D structure
PDB8tdb Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
ChainA
Resolution2.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI A G7 A8 G9 Q10 L11 S34 P35 N56 V70 K71 P72 I78 A96 A97 T122 T124 G7 A8 G9 Q10 L11 S34 P35 N56 V70 K71 P72 I78 A96 A97 T122 T124
BS02 GHO A V231 S233 T238 V231 S233 T238
Gene Ontology
Molecular Function
GO:0004735 pyrroline-5-carboxylate reductase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0006561 proline biosynthetic process
GO:0034599 cellular response to oxidative stress
GO:0051881 regulation of mitochondrial membrane potential
GO:0055129 L-proline biosynthetic process
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tdb, PDBe:8tdb, PDBj:8tdb
PDBsum8tdb
PubMed39133178
UniProtP32322|P5CR1_HUMAN Pyrroline-5-carboxylate reductase 1, mitochondrial (Gene Name=PYCR1)

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