Structure of PDB 8tci Chain A

Receptor sequence

>8tciA (length=283) Species: 10090 (Mus musculus) [Search protein sequence]

KRRPIRVLSLFDGIATGYLVLKELGIKVEKYIASEVCAESIAVGTVKHEG
QIKYVDDIRNITKEHIDEWGPFDLVIGGSPCNDLSCVNPVRKGLFEGTGR
LFFEFYRLLNYSCPEEEDDRPFFWMFENVVAMEVGDKRDISRFLECNPVM
IDAIKVSAAHRARYFWGNLPGMNRPVMASKNDKLELQDCLEFSRTAKLKK
VQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPEHYTDVSN
MGRGARQKLLGRSWSVPVIRHLFAPLKDHFACE

3D structure

PDB

8tci The structure of DNA methyltransferase DNMT3C reveals an activity-tuning mechanism for DNA methylation.

Chain

Resolution

3.19 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	P546 V591 S665 R710	P89 V134 S208 R253
BS02	dna	A	S536 C538 N539 C543 V544 N545 E584 N585 V586 R620 Q659 T660 T663 K664 G718 R719	S79 C81 N82 C86 V87 N88 E127 N128 V129 R163 Q202 T203 T206 K207 G261 R262
BS03	SAH	A	F468 D469 E492 V493 D514 I515 G535 R719 S720 W721	F11 D12 E35 V36 D57 I58 G78 R262 S263 W264

External links

PDB	RCSB:8tci, PDBe:8tci, PDBj:8tci
PDBsum	8tci
PubMed	39098534
UniProt	P0DOY1\|DNM3C_MOUSE DNA (cytosine-5)-methyltransferase 3C (Gene Name=Dnmt3c)

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